Macromolecular therapeutics
نویسندگان
چکیده
منابع مشابه
Enhancing Endosomal Escape for Intracellular Delivery of Macromolecular Biologic Therapeutics
Bioactive macromolecular peptides and oligonucleotides have significant therapeutic potential. However, due to their size, they have no ability to enter the cytoplasm of cells. Peptide/Protein transduction domains (PTDs), also called cell-penetrating peptides (CPPs), can promote uptake of macromolecules via endocytosis. However, overcoming the rate-limiting step of endosomal escape into the cyt...
متن کاملTumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
Most solid tumors possess unique pathophysiological characteristics that are not observed in normal tissues or organs, such as extensive angiogenesis and hence hypervasculature, defective vascular architecture, impaired lymphatic drainage/recovery system, and greatly increased production of a number of permeability mediators. The phenomenon now known as the enhanced permeability and retention (...
متن کاملFunctionalized CNTs for delivery of therapeutics
Carbon nanotubes (CNTs) are high aspect ratio allotropes of carbon. Because of their unique physical and chemical characteristics, they are nominated for a vast variety of applications in the biomedical field. Their very low solubility is the only problem of them which is solved by different methods of Functionalization. After discoveries in the last few years of the capacity of CNTs to penetra...
متن کاملFunctionalized CNTs for delivery of therapeutics
Carbon nanotubes (CNTs) are high aspect ratio allotropes of carbon. Because of their unique physical and chemical characteristics, they are nominated for a vast variety of applications in the biomedical field. Their very low solubility is the only problem of them which is solved by different methods of Functionalization. After discoveries in the last few years of the capacity of CNTs to penetra...
متن کاملA new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.
We previously found that a polymer conjugated to the anticancer protein neocarzinostatin, named smancs, accumulated more in tumor tissues than did neocarzinostatin. To determine the general mechanism of this tumoritropic accumulation of smancs and other proteins, we used radioactive (51Cr-labeled) proteins of various molecular sizes (Mr 12,000 to 160,000) and other properties. In addition, we u...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2014
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2014.04.013